What is transaminase got ast?
Aspartate transaminase is an enzyme belonging to the class of transferases. It is also known as aspartate aminotransferase or by its old English name Serum Glutamic Oxaloacetic Transaminase. The enzyme catalyzes the following reaction: L-aspartate + α-ketoglutarate ⇌ oxaloacetate + L-glutamate
AST - GOT or aspartate aminotransferase - is an enzyme that belongs to the class of transferases and, unlike alanine aminotransferase (ALT), is present in many tissues, such as the liver, heart, skeletal muscles, brain and kidney. AST is released into the blood in proportion to the extent of cell damage.
The first, in the past also known by the acronym GOT (glutamate oxaloacetate transaminase), uses aspartate to produce glutamic acid; the second, formerly known as GPT (glutamate pyruvate transaminase), always produces glutamic acid but using alanine as the starting amino acid.
As for extra-hepatic causes, the increase in transaminases may be due to hypothyroidism, celiac disease, food allergies, chronic intestinal diseases, dehydration, heat stroke, acute pancreatitis, myocardial infarction and musculoskeletal trauma.
GPT (Alanine Aminotransferase - ALT) is an enzyme that belongs to the class of transferases and is found mainly inside the liver.
High levels of got and more of gpt transaminases occur in hepatitis (hepatitis A, hepatitis B, hepatitis C), myocardiopathies, acute myocardial infarction, myocarditis, pericarditis, heart failure, infectious mononucleosis and liver diseases in general.
Instead, among the foods recommended in case of high transaminases we find pasta, rice, low-fat yogurt, fresh fruit, fresh vegetables except peppers, cauliflower, broad beans, peas and mushrooms. Care should also be taken not to overdo it with meat, eggs and fatty cold cuts.
They can be defined as very high, when the numbers exceed the reference levels by at least 10 units. In these cases, the liver problem is serious and it is important to intervene immediately. This could be ischemic hepatitis, acute viral hepatitis, or high drug ingestion that has been found to be toxic.
- water, soft drinks and non-carbonated juices;
- lean meats and all kinds of fish;
- pasta, rice, bread and boiled potatoes;
- low-fat cheeses and lean ham;
- skim milk and low-fat yoghurt;
- fresh vegetables and fresh fruit;
- simple desserts such as honey or jam tarts.
When the gluten-free diet is started, the transaminases normalize within 6 months (if the alterations persist, another cause must be sought). The search for tissue anti-transglutaminase antibodies allows a safe and non-invasive diagnosis of celiac disease19.
Extremely high transaminase values indicate acute liver cell necrosis or liver damage due to: Acute viral hepatitis; Hepatitis induced by toxins or drugs; Ischemic hepatitis or hepatic infarction.
Making changes to your diet is important for lowering transaminase levels, so the following is recommended: Follow a diet that is low in fat and free from fried, breaded, and fast foods. The intake of fatty meats should be limited and replaced by the consumption of lean meats.
Gamma-glutamyl transferase (GGT) can be used to determine the cause of an increase in alkaline phosphatase (ALP). Both ALP and GGT can increase in bile duct diseases and some liver diseases, but only ALP values increase in bone diseases.
Alanine amino transferase (ALT) is an enzyme found mainly in liver and kidney cells; much smaller amounts are also found in the heart and muscles.
Among the fruit, the banana I would leave aside, I would choose peach, plum, apple, pear, melon ... I would also try to drink about 8-10 glasses of water a day, avoiding alcohol, spirits and beer.
A classic remedy for detoxifying the liver is to drink warm-warm water and lemon in the morning, at least 15 minutes before breakfast. Other natural remedies can be Aloe vera juice or birch sap, both to be taken in the morning on an empty stomach and in the evening before going to bed.
Let's now see the normal reference values of ALT transaminases: Men: from 1 to 43 U / L (Units per liter of blood); Women: from 1 to 36 U / L.
How to lower the GGT enzyme with food
It is necessary to eliminate animal fats, red meat and cured meats (which are rich in saturated fat) at least for a considerable period. The right foods to start healthy again are lean proteins, white meats and blue fish.
- Sedative-hypnotics, such as carbamazepine and phenobarbital;
- Antibiotics and antibacterials, such as clindamycin, nitrofurantoin and sulfonamides;
- ACE inhibitors, such as captopril and enalapril;
- Phenytoin (an antiepileptic);
- Ciproeptadine (an antihistamine);
It is important to underline that the negativity in the examination of GGT does not exclude alcoholism; in fact, the serum values of these enzymes tend to drop already in the first week of suspension of alcoholic consumption, and to normalize within fifteen days.
What are the causes of steatosis? Fatty liver occurs when there is an alteration in the liver cells, which store more fat than they are able to dispose of. This condition can be due to several factors: Diets too high in fat, generally associated with overweight or obesity
Glutamate-oxaloacetate transaminase GOT, also called aspartate aminotransferase AST (mainly localized in myocardium, skeletal muscles, kidney, brain, liver) Glutamate-pyruvate transaminase GPT, also called alanine aminotransferase ALT (present in great concentration in liver cells)
In practice, the GT range makes it possible to distinguish whether this result is attributable to the liver or to the bones. High values of Gamma Glutamyl Transferase can be an indicator of: Liver diseases (hepatitis of viral origin, cirrhosis, tumor forms or therapy with drugs toxic to the liver);
In fact, even in the normal adult there are traces of this substance (up to 10-15 nanograms per milliliter), but values over 200 must be considered highly suspicious for the presence of a liver tumor.
When the values are very high (above 1000 mg / dl), there is a risk of developing pancreatitis, i.e. inflammation of the pancreas. In these cases, the doctor should immediately prescribe a treatment to reduce triglycerides.